New insights on the mechanisms of transmission of bacterial pathogen that causes listeriosis

Listeriosis is a zoonotic illness of meals origin that may trigger, each within the human species and in animals, signs of gastroenteritis, meningitis, bacteremia and miscarriages. The pathogen that causes this an infection is the Listeria micro organism. Juan José Quereda, researcher with a Ramón y Cajal contract and professor on the CEU Cardenal Herrera College (CEU UCH), the place he leads the analysis group on Intracellular Pathogens, has been conducting analysis on this area since 2011. Professor Quereda has simply printed new advances, in collaboration with researchers from the Pasteur Institute in Paris, the College of Iowa and the CNB-CSIC in Madrid, on the mechanisms of transmission of this pathogen, its genetic traits, antibiotic resistance and its seasonal presence in dairy farms, which might contribute to designing simpler measures to curb its proliferation and develop new therapies in opposition to an infection.

Along with researchers from the Pasteur Institute in Paris and the College of Iowa, Professor Quereda has participated within the research of Listeriolysin S, a bacteriocin synthesized by this bacterium to facilitate intestinal colonization, altering the microbiota, and likewise selling its growth to different organs. On this research, led by Dr. Javier Pizarro Cerdá and printed within the journal Proceedings of the Nationwide Academy of Sciences (PNAS), they’ve discovered the mechanism of permeabilization of the bacterial membrane mediated by Listeriolysin S that facilitates its dissemination within the organism.

Dangers of uncooked milk

One other of the latest findings led by Professor Quereda, lead researcher of the Group “Intracellular Pathogens: Biology and An infection”, has centered on the seasonal nature of the incidence of Listeria in dairy farms, in a research carried out along with researchers from the Division of Animal Manufacturing and Well being of the CEU UCH, together with the ProVaginBIO Group, led by Professor ángel Gómez Martín. The evaluation of the epidemiology and genetic range of Listeria in 19 farms has made it doable to detect that the presence of the micro organism varies at completely different occasions of the 12 months: it will increase in cows in winter and in sheep in winter and spring. The research has proven that farms could be a reservoir of hypervirulent variants of Listeria, which makes it advisable to bolster hygiene measures, particularly in durations of larger threat of prevalence. Additionally it is advisable to keep away from the consumption of untreated uncooked milk to eradicate the danger of pathogens equivalent to Listeria, which dies at temperatures above 65 °C.

This research concerned the professors and researchers from the Division of Animal Manufacturing and Well being, Veterinary Public Well being and Meals Science and Know-how of the College of Veterinary Medication of the CEU UCH Carla Palacios, Jesús Gomis, ángel Gómez, María Mocé, Estrella Jiménez, ángel García and Juan José Quereda; and Professor Empar García from the Division of Medication and Animal Surgical procedure, in addition to researchers from the Pasteur Institute of Paris, led by Dr. Marc Lecuit.

Reviewer at Virulence and editor of Frontiers

Given his analysis expertise within the research of Listeria, Professor Quereda has participated in a gaggle of consultants led by the CNB-CSIC Nationwide Centre of Biotechnology, and significantly by the medical doctors Graciela Pucciarelli and álvaro Ortega, who’ve printed within the journal Virulence, a assessment of the newest findings on this bacterium. The publication is at the moment a reference supply for researchers working with this micro-organism at worldwide stage.

As well as, Professor Quereda has simply been elected because the Affiliate Editor of the journal Frontiers in Microbiology, a number one scientific publication within the area of microbiology, to judge the analysis submitted for publication on this journal, for the part ‘Infectious Brokers and Illness’.

Dr. Juan José Quereda Torres has labored within the space of Animal Genetics and Well being of the College of Murcia (2006-2011), within the CNB-CSIC Laboratory of Intracellular Pathogenic Micro organism of the Nationwide Centre of Biotechnology of Madrid (2011-2014), and within the Micro organism-Cell Interactions Unit of the Pasteur Institute of Paris (2014-2017). After becoming a member of the College of Veterinary Medication of the CEU UCH, Juan José Quereda was chosen because the beneficiary of a contract by the Ramón y Cajal programme of the Spanish Ministry of Science, Innovation and Universities, which he’s at the moment fulfilling at this College.