A analysis workforce from LKS School of Drugs, the College of Hong Kong (HKUMed) has developed thyroid hormone (TH) – encapsulated nanoparticles modified with adipose-homing peptide, which selectively transport TH to adipose tissues. 

The researchers say this can advance the therapy of obesity-related medical problems with TH by overcoming its extreme adversarial results attributable to systemic administration. The brand new findings have been revealed in Nature Communications.

Weight problems is a significant danger issue for a myriad of life-threatening continual ailments reminiscent of diabetes, cardiovascular; and neurodegenerative issues. TH is an historic hormone with therapeutic potential for weight problems and its associated medical problems by selling vitality expenditure. Nevertheless, regardless of analysis efforts previously, medical trials didn’t exhibit any apparent medical advantages of continual systemic administration of TH on weight reduction in overweight people. Moreover, because of widespread expression of TH receptors, systemic administration of TH typically results in severe deleterious results on a number of organs, reminiscent of tachycardia, coronary heart assault, muscle losing, and osteoporosis. 

Skeletal muscle and adipose tissues are considered the 2 main goal organs the place TH exerts its stimulatory actions on metabolic fee and vitality expenditure. Nevertheless, whether or not selective supply of TH to adipose tissues is enough to induce weight reduction stays unclear.

HKUMed analysis and outcomes

The HKUMed analysis workforce developed TH-encapsulated nanoparticles, modified with an adipose-homing peptide to selectively ship TH to adipose tissues. The researchers discovered that adipose-targeted supply of TH is considerably stronger than systemic TH remedy in decreasing weight problems and its associated metabolic problems, with no adversarial impact on different non-adipose tissues. 

Mechanistically, the examine uncovered that adipose-targeted TH remedy can convert ‘unhealthy’ white fats to ’good’ brown fats, which might burn energy by creating warmth, whereas systemic TH remedy is unable to induce ‘browning’ of white fats because of its suppression of sympathetic nerves. Moreover, the analysis workforce made an surprising discovering that adipose-targeted supply of TH successfully alleviates hypercholesterolemia and atherosclerosis, a significant explanation for coronary coronary heart illness and ischemic stroke.

Analysis significance

“That is the primary proof-of-concept examine displaying that nanoparticle-based focused supply of TH to adipose tissue is an efficient and secure pharmacotherapy for weight problems and its associated cardiometabolic problems,” stated Xu Aimin, director of State Key Laboratory of Pharmaceutical Biotechnology and professor of Division of Drugs, Faculty of Scientific Drugs, HKUMed. 

“The findings have additionally resolved a long-standing thriller of why systemic TH remedy failed to cut back physique weight, thus reigniting the hope of utilizing this historic hormone for therapy of widespread continual ailments by nanoparticle-based precision goal supply.”

In regards to the analysis workforce at HKUMed

The analysis workforce is led by Xu Aimin and Wang Weiping, assistant professor of Dr Li Dak-Sum Analysis Centre and Division of Pharmacology and Pharmacy, HKUMed. Chen Kang, a post-doctoral fellow of State Key Laboratory of Pharmaceutical Biotechnology and Division of Drugs, Faculty of Scientific Drugs, HKUMed is the primary writer.

Eric Honoré from Université Côte d’Azur, Centre Nationwide de la Recherche Scientifique, Institut Nationwide de la Santé et de la Recherche Médicale, Institut de Pharmacologie Moléculaire et Cellulaire and Karen Lam Siu-ling from State Key Laboratory of Pharmaceutical Biotechnology and Division of Drugs, Faculty of Scientific Drugs, HKUMed, are co-authors.

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