Organic science offers with the human cell. Cells that precisely mimic human illness are basic for discovery of recent medicine. Nonetheless, in a sea of cells engineered to mannequin illness, solely a tiny quantity are appropriate. Detecting and isolating the optimum cells is very troublesome. Chromovert® Expertise facilitates the detection and purification of even exceedingly uncommon, desired cells that had beforehand remained out-of-reach.

Chromovert® was invented by Dr. Kambiz Shekdar within the laboratory of the late Gunter Blobel, MD, PhD, 1999 recipient of the Nobel Prize in Physiology or Drugs, and John D. Rockefeller, Jr. Professor and Howard Hughes Medical Institute Investigator at The Rockefeller College in New York Metropolis. Chromocell Therapeutics CEO Christian Kopfli, Drs. Shekdar and Blobel co-founded Chromocell Company the place Dr. Shekdar served as Chief Scientific Officer as a spin-out of The Rockefeller College.

Whereas Chromovert® was pioneered within the U.S., Dr. Shekdar is transitioning it to the UAE by way of his second firm, Secondcell Bio. Excessive value and inertia amongst entrenched groups stay as limitations to many broad-based next-generation applied sciences.

Just lately, the UAE has dedicated to creating its non-oil economic system. UAE teams together with the sovereign wealth fund Mubadala and Dubai Future Basis are investing within the nation’s non-oil economic system, together with the life sciences and biotechnology. As a result of there isn’t a legacy biotechnology within the UAE, stakeholders can cherry-pick from their alternative of cutting-edge improved applied sciences to make leap-frog advances over the trade.

“Within the UAE, there isn’t a legacy pharma trade, no dinosaurs to shove out of the way in which,” says Dr. Shekdar. “Chromovert® is a disruptive platform expertise that opens the floodgates to usher in an period of accelerated drug discovery.”

The failure price within the pharmaceutical trade for the invention and growth of recent medicine is a staggering 98%. This factors to a dire want for enhancements in any respect levels of the method. Chromovert® has been demonstrated to enhance upon the method. The now validated expertise is basically automated and scalable to quite a few medical purposes and desires. 

Drug makers earn an estimated common $18.6 billion USD in world income per new drug. Present excessive common failure charges within the drug discovery and growth course of drive up the typical value of creating every new drug to over $1.8 billion USD.

The automated, extra dependable, and less expensive nature of the Chromovert-enabled course of permits a paradigm shift: quite a few drug discovery packages could also be pursued in parallel to yield quite a few drug candidates for commercialization directly, all with a better general probability of success in comparison with conventional efforts.

A primary-hand account of the rising biotech sector within the UAE is accessible in Dr. Shekdar’s month-to-month column in WestView Information, a New York Metropolis newspaper the place the inventor is Science Editor (See https://westviewnews.org/2023/01/17/from-oil-to-medicine/james/).

About Secondcell Bio & Chromovert® Expertise 

Secondcell Bio is a life sciences firm established to appreciate the fullest attainable potential of Chromovert® Expertise for science and human well being. Chromovert® Expertise automates and improves the creation of laboratory cells that extra precisely mimic human illness, allowing the invention of superior drug candidates with a better general probability of success all through the rest of the prolonged and costly course of to develop new medicine. The expertise has already been validated and efficiently commercially utilized to a various vary of extremely sought however beforehand out-of-reach targets. Strategic collaborations with The Coca-Cola Firm, Kraft Meals and Nestle used Chromovert® to find uncommon pure taste substances to be used to chop salt and sugar within the weight loss program. The expertise was additionally used to find and develop a novel clinical-stage non-addictive ache blocker that was fast-tracked by the FDA and introduced at Gov. Chris Christie’s panel on the opioid epidemic at The White Home. The ache blocker is now the topic of an upcoming IPO by Chromocell Therapeutics. Chromovert® was invented by Dr. Kambiz Shekdar, PhD within the laboratory of his late mentor and doctoral diploma advisor, King Faisal & Nobel Prize winner Rockefeller College Professor Dr. Gunter Blobel, MD, PhD. Greater than $100 million USD was invested to excellent the expertise which is now prepared for drug discovery at scale™ within the UAE.

For the scientific publication of Chromovert® Expertise by Nature Springer, go to: https://link.springer.com/article/10.1007/s10529-021-03101-5.



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